What the papers say: p53 Loss of Function: Implications for the Processes of Immortalization and Tumorigenesis
- 1 August 1992
- Vol. 14 (8) , 557-560
- https://doi.org/10.1002/bies.950140811
Abstract
The complex process of cell immortalization and transformation is likely to involve the inactivation of growth regulatory genes. Mutations (deletions, missense mutations) in the p53 gene are the most frequently observed genetic alteration in human tumors, making p53 a candidate for a cellular protein involved in the control of cell growth. Two recent studies have examined the role of p53 in immortalization and tumorigenesis(27,28). In the first study(27), p53 expression was examined in both mortal and immortal chick embryo fibroblasts. All mortal clones expressed p53 but the loss of wild‐type p53 expression was observed in every immortal cell line examined. In the second study(28), a line of mice carrying two null p53 alleles has been created and characterized. Although these mice develop normally, they show a predisposition to develop a variety of neoplasms at an early age (< 6 months). Although it is unclear whether p53 regulates the same, different, or overlapping pathways in the two experimental systems, these data demonstrate that p53 function is critical for the maintenance of normal growth control and support the current classification of p53 as a growth suppressive or tumor suppressor gene.Keywords
This publication has 28 references indexed in Scilit:
- Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation.Genes & Development, 1992
- Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursNature, 1992
- p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.Genes & Development, 1991
- The p53 tumour suppressor geneNature, 1991
- Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other NeoplasmsScience, 1990
- Mutations in the p53 gene occur in diverse human tumour typesNature, 1989
- Chromosome 17 Deletions and p53 Gene Mutations in Colorectal CarcinomasScience, 1989
- Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 geneCell, 1984
- Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cellsCell, 1982
- T antigen is bound to a host protein in SY40-transformed cellsNature, 1979