The hydrolysis of glycerophosphocholine by rat brain microsomes: Activation and inhibition
- 1 February 1987
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 12 (2) , 203-206
- https://doi.org/10.1007/bf00979538
Abstract
Experiments with glycerophosphocholine phosphodiesterase (GPC diesterase, EC 3.1.4.2.) in rat brain microsomes suggest that, although its activity is inhibited by low concentrations of calmidazolium, its dependence on Ca2+ ions is not modulated by calmoulin. The activity of glycerophosphocholine choline phosphodiesterase (choline phosphohydrolase, EC 3.1.4.38) was much lower than that of the GPC diesterase. A relatively inexpensive method for the preparation ofsn-glycero-3-phospho [Me-14C]choline is described.Keywords
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