The Management of Depression in Hospital

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Abstract
Desipramine (Pertofran) is a metabolite of imipramine (Tofranil) originally isolated by Herrmann, Schindler and Pulver (1959) and found to be identical with the synthetic compound G.35025. Animal experiments (Gillette et al., 1961) suggest a more rapid action for desipramine, and the majority of clinical trials to date confirm this impression for humans (e.g. Kline et al., 1962; Krakowski, 1963). Some controlled trials, however, (Azima et al., 1962; Hollister et al., 1963) fail to establish that desipramine is either faster acting or more effective than imipramine.