The Thyrotropin Receptor in Thyroid Diseases
- 4 December 1997
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 337 (23) , 1675-1681
- https://doi.org/10.1056/nejm199712043372307
Abstract
The growth and function of the thyroid are controlled by thyrotropin1 through the activation of its receptor, which belongs to the large family of G protein–coupled receptors. Despite the extreme diversity of their ligands, all receptors from this family have a common molecular architecture: seven transmembrane segments, three extracellular loops, three intracellular loops, an extracellular amino terminal, and an intracytoplasmic carboxy terminal (Figure 1). The glycoprotein hormone receptors constitute a subfamily that is characterized mainly by a particularly long amino-terminal extracellular domain that confers binding specificity.1,21 The thyrotropin receptor is encoded by 10 exons spread over 58 kilobases on . . .Keywords
This publication has 47 references indexed in Scilit:
- Diversity and Prevalence of Somatic Mutations in the Thyrotropin Receptor and Gs Genes as a Cause of Toxic Thyroid AdenomasJournal of Clinical Endocrinology & Metabolism, 1997
- Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformationJournal of Clinical Endocrinology & Metabolism, 1996
- Thyrotropin receptor gene alterations in thyroid hyperfunctioning adenomasJournal of Clinical Endocrinology & Metabolism, 1996
- Rarity of oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in JapanJournal of Clinical Endocrinology & Metabolism, 1995
- Somatic and germline mutations of the TSH receptor gene in thyroid diseasesJournal of Clinical Endocrinology & Metabolism, 1995
- Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroidJournal of Clinical Endocrinology & Metabolism, 1994
- Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsyJournal of Clinical Endocrinology & Metabolism, 1994
- Autoimmune endocrinopathies 2 Recombinant thyroid autoantigens: the keys to the pathogenesis of autoimmune thyroid diseaseJournal of Internal Medicine, 1993
- Abnormalities in G protein-coupled signal transduction pathways in human disease.Journal of Clinical Investigation, 1993
- Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction—primer-introduced restriction analysisCancer, 1993