The Production of Colony-Stimulating Factors by Thyroid Carcinoma Is Associated with Marked Neutrophilia and Eosinophilia.
- 1 January 1996
- journal article
- case report
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 35 (10) , 815-820
- https://doi.org/10.2169/internalmedicine.35.815
Abstract
Cancers producing colony-stimulating factors and associated with marked leukocytosis are relatively rare. We report here a case of a thyroid cancer producing both granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). A 72-year-old woman had a thyroid carcinoma with significant neutrophilia and eosinophilia without any evidence of infection. The serum concentrations of both G-CSF and GM-CSF were elevated significantly in this patient, which might have induced the leukocytosis. Furthermore, the G-CSF concentrations in thyroid tumor tissue and metastatic lesions in the lung and skin examined at autopsy also were extremely high.Keywords
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