The histone database: A comprehensive resource for histones and histone fold‐containing proteins
- 12 December 2005
- journal article
- research article
- Published by Wiley in Proteins-Structure Function and Bioinformatics
- Vol. 62 (4) , 838-842
- https://doi.org/10.1002/prot.20814
Abstract
TheThe Histone Database is a curated and searchable collection of full‐length sequences and structures of histones and nonhistone proteins containing histone‐like folds, compiled from major public databases. Several new histone fold‐containing proteins have been identified, including the huntingtin‐interacting protein HYPM. Additionally, based on the recent crystal structure of the Son of Sevenless protein, an interpretation of the sequence analysis of the histone fold domain is presented. The database contains an updated collection of multiple sequence alignments for the four core histones (H2A, H2B, H3, and H4) and the linker histones (H1/H5) from a total of 975 organisms. The database also contains information on the human histone gene complement and provides links to three‐dimensional structures of histone and histone fold‐containing proteins. The Histone Database is a comprehensive bioinformatics resource for the study of structure and function of histones and histone fold‐containing proteins. The database is available at http://research.nhgri.nih.gov/histones/. Proteins 2006.Keywords
This publication has 19 references indexed in Scilit:
- A gene atlas of the mouse and human protein-encoding transcriptomesProceedings of the National Academy of Sciences, 2004
- MUSCLE: multiple sequence alignment with high accuracy and high throughputNucleic Acids Research, 2004
- Tandem Histone Folds in the Structure of the N-Terminal Segment of the Ras Activator Son of SevenlessStructure, 2003
- Phylogenomics of the nucleosomeNature Structural & Molecular Biology, 2003
- Multiple sequence alignment with the Clustal series of programsNucleic Acids Research, 2003
- Nucleosomes Unfold Completely at a Transcriptionally Active PromoterMolecular Cell, 2003
- Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's DiseaseScience, 2002
- The Histone DatabaseNucleic Acids Research, 2002
- Translating the Histone CodeScience, 2001
- Histone H1 diversity: bridging regulatory signals to linker histone functionGene, 2001