Engraftment with Chronic Granulocytic Leukemia Cells in Acute Myeloid Leukemia

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Abstract
A deliberate engraftment with nonirradiated chronic granulocytic leukemia (CGL) cells was performed in a patient with acute myeloid leukemia (AML) at a time when he was resistant to cytotoxic drug chemotherapy, pancytopenic and developed an infection. The CGL engraftment was confirmed by the presence of a Ph1‐positive donor clone in the recipient's bone marrow and by the pattern of colony growth of the recipient's bone‐marrow cells cultured in vitro. Bone marrow engraftment in the host helped in the resolution of infection and permitted the administration of further cytotoxic drugs, as a result of which a remission of AML occurred.