Repeated blood pressure measurements in a sample of Swedish twins: heritabilities and associations with polymorphisms in the renin-angiotensin-aldosterone system
- 1 August 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Journal Of Hypertension
- Vol. 20 (8) , 1543-1550
- https://doi.org/10.1097/00004872-200208000-00017
Abstract
Twin and family studies have shown that genetic effects explain a relatively high amount of the phenotypic variation in blood pressure. However, many studies have not been able to replicate findings of association between specific polymorphisms and diastolic and systolic blood pressure. In a structural equation-modelling framework the authors investigated longitudinal changes in repeated measures of blood pressures in a sample of 298 like-sexed twin pairs from the population-based Swedish Twin Registry. Also examined was the association between blood pressure and polymorphisms in the angiotensin-I converting enzyme and the angiotensin II receptor type 1 with the ‘Fulker’ test. Both linkage and association were tested simultaneously revealing whether the polymorphism is a Quantitative Trait Locus (QTL) or in linkage disequilibrium with the QTL. Genetic influences explained up to 46% of the phenotypic variance in diastolic and 63% of the phenotypic variance in systolic blood pressure. Genetic influences were stable over time and contributed up to 78% of the phenotypic correlation in both diastolic and systolic blood pressure. Non-shared environmental effects were characterised by time specific influences and little transmission from one time point to the next. There was no significant linkage and association between the polymorphisms and blood pressure. There is a considerable genetic stability in both diastolic and systolic blood pressure for a 6-year period of time in adult life. Non-shared environmental influences have a small long-term effect. Although associations with the polymorphisms could not be replicated, results should be interpreted with caution due to power considerations.Keywords
This publication has 36 references indexed in Scilit:
- Heritability of Central Systolic Pressure AugmentationHypertension, 2000
- Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetesJournal Of Hypertension, 1999
- Maximum-Likelihood Generalized Heritability Estimate for Blood Pressure in Nigerian FamiliesHypertension, 1999
- Heritability of blood pressure increases during mental stressTwin Research, 1998
- Heritability of Conventional and Ambulatory Blood PressuresHypertension, 1995
- Genetic influences on ambulatory blood pressure patterns*The Medical College of Virginia twin studyAmerican Journal of Hypertension, 1995
- Genetic and environmental influences on blood pressure in elderly twins.Hypertension, 1994
- No effect of insertion/ deletion polymorphism at the ACE locus on normal blood pressure level or variabilityClinical Genetics, 1994
- Genetic and environmental effects on blood pressure in a Norwegian sampleGenetic Epidemiology, 1992
- Family Resemblance for Blood PressureHuman Heredity, 1983