ACROMEGALY AND PITUITARY ADENOMA WITH PHAEOCHROMOCYTOMA: A VARIANT OF MULTIPLE ENDOCRINE NEOPLASIA

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Abstract
Two women had acromegaly due to a pituitary adenoma associated with pheochromocytoma. Eight additional patients with this combination of tumors have been described by others. The 1st patient had sustained hypertension, mild hypercalcemia, and elevated basal levels of parathyroid hormone [PTH] and calcitonm [CT] associated with malignant pheochromocytoma and parathyroid hyperplasia. The 2nd patient had episodic hypertension and normal basal serum Ca, PTH and CT levels with a benign cystic pheochromocytoma. Four of the 10 patients died from causes related to the pheochromocytoma. Three patients had parathyroid hyperplasia. A separate group of 4 patients with pheochromocytoma and pituitary adenoma without acromegaly has also been reported. These 14 patients probably represent a non-familial variant of the multiple endocrine neoplasia syndrome. Acromegalic patients with hypertension evidently should be screened for pheochromocytoma.