Cytotoxic principles From the Sap of Kalmia latifolia
- 1 September 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 42 (5) , 483-488
- https://doi.org/10.1021/np50005a008
Abstract
Examination of the sap of K. latifolia revealed grayanotoxin I (1), phloretin (3) and 2'',6''-dihydroxy-4-methoxyacetophenone (5) as cytotoxic components. Twenty-one dihydrochalcones were synthesized and tested for cytotoxic activity [using human nasopharyngeal carcinoma 9KB cells]. 2'',3,3'',4,4''-Pentahydroxydihydrochalcone (8) was cytotoxic and had marginal [antineoplastic] activity in vivo. Seven new dihydrochalcones are described.This publication has 1 reference indexed in Scilit:
- Uvaretin, a new antitumor agent from Uvaria acuminata (Annonaceae)The Journal of Organic Chemistry, 1976