Study of Estrogen Production in Women with Hydatidiform Mole

1 August 1964

journal article
research article
Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism

Vol. 24 (8) , 685-690
https://doi.org/10.1210/jcem-24-8-685

Abstract

Following the intravenous administration of a tracer dose of 6,7-³Hestradiol-17β to 3 women with hydatidiform mole, urine was collected for 6 days. Estrone, estradiol and estriol were isolated from each 6-day urine collection and their specific activities were determined. The specific activity of estriol was slightly lower (13–32 %) than that of estrone or estradiol. Based on the dilution of the injected tracer according to the cumulative specific activity of urinary estradiol, the production rate of estradiol in these 3 subjects was 6.7, 7.4 and 11.0 mg/day.

Keywords

ESTRONE
URINE
URINE SPECIMEN COLLECTION
INTRAVENOUS ROUTE OF DRUG ADMINISTRATION
DILUTION TECHNIQUE
DILUTE (ACTION)
URINARY TRACT

This publication has 2 references indexed in Scilit:

The isolation of urinary estrogens and determination of their specific activities following the administration of radioactive precursors to humans
Steroids, 1963
A DISCUSSION OF THE ISOTOPE DILUTION METHOD FOR ESTIMATING SECRETORY RATES FROM URINARY METABOLITES
Acta Endocrinologica, 1962