PTPN22: Its role in SLE and autoimmunity
- 1 January 2007
- journal article
- review article
- Published by Taylor & Francis in Autoimmunity
- Vol. 40 (8) , 582-590
- https://doi.org/10.1080/08916930701510848
Abstract
A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. In this review, we discuss the structure and function of this gene and its disease-associated polymorphisms. In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases.Keywords
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