A New Adjacent Bis-Tetrahydrofuran Annonaceous Acetogenin from the Seeds ofUvaria chamae
- 25 July 2006
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 72 (10) , 938-940
- https://doi.org/10.1055/s-2006-941542
Abstract
A novel acetogenin, joolanin (1), along with eight known acetogenins, squamocin (2), desacetyluvaricin (3), chamuvarinin (4), tripoxyrollin (5), diepoxyrollin (6), dieporeticanin-1 (7), dieporeticanin-2 (8) and dieporeticenin (9) were isolated from the seeds of Uvaria chamae (Annonaceae). Compound 1, the first adjacent bis-tetrahydrofuranic ring acetogenin bearing a ketone group at C-5, shows significant cytotoxicity towards the KB 3 - 1 cell line (IC50 = 0.4 nM).Keywords
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