Topical application of NADH for the treatment of rosacea and contact dermatitis
- 28 January 2003
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Dermatology
- Vol. 28 (1) , 61-63
- https://doi.org/10.1046/j.1365-2230.2003.01118.x
Abstract
Among many important physiological functions played by NADH (the reduced form of beta-nicotinamide adenine dinucleotide) its antioxidative properties are remarkable. Acting directly as an antioxidant, NADH can effectively protect the cell and its membrane from destruction by free radicals. NADH can be stabilized as a suspension in hydrophobic ointments prepared in a way that prevents contact with atmosphere containing oxygen and water. We present the first report of NADH as a treatment for some inflammatory dermatoses. It was found that topical application of 1% NADH diluted in Vaseline ointment can be very effective in the treatment of rosacea and contact dermatitis. Since no adverse effects were observed, therapy with NADH can be viewed as a potential alternative to other established treatments.Keywords
This publication has 16 references indexed in Scilit:
- NAD(P)H, a directly operating antioxidant?The FASEB Journal, 2001
- Hydrogen-Transferred Radical Cations of NADH Model Compounds. 3. 1,8-AcridinedionesThe Journal of Physical Chemistry A, 2000
- Hydrogen-Transferred Radical Cations of NADH Model Compounds. 2. Sequential Electron−Proton Addition to NAD+The Journal of Physical Chemistry A, 2000
- Hydrogen-Transferred Radical Cations of NADH Model Compounds. 1. Spontaneous TautomerizationJournal of the American Chemical Society, 2000
- Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndromeAnnals of Allergy, Asthma & Immunology, 1999
- A survey of reactive oxygen species and their role in dermatologyJournal of the European Academy of Dermatology and Venereology, 1997
- A survey of reactive oxygen species and their role in dermatologyJournal of the European Academy of Dermatology and Venereology, 1997
- Structural Aspects and Rearrangement of Radical Cations Generated from NADH AnaloguesJournal of the American Chemical Society, 1996
- Equilibrium of 5,6-hydration of NADH and mechanism of ATP-dependent dehydrationBiochemistry, 1988
- Reactions of reduced nicotinamide adenine dinucleotide in acid: studies by reversed-phase high-pressure liquid chromatographyBiochemistry, 1978