Asthma due to non‐occupational exposure to toluene (tolylene) di‐isocyanate

Abstract
The production of asthma by toluene di-isocyanate, aspirated into the ventilating system and emanating from the exhausts of a neighboring factory, was established in 3 otherwise non-exposed clerical workers. Occupational-type exposure tests with a polyurethane varnish/toluene di-isocyanate mixture elicited vigorous and prolonged non-immediate asthmatic reactions, thus enabling identification of the otherwise, obscure etiological cause of their asthma. The probability of an allergic etiology is discussed.

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