Effect of Cholecystokinin-Octapeptide on Total Parenteral Nutrition-Induced Changes in Hepatic Bile Secretion and Composition in the Rat

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Abstract
These studies investigated the ability of twice-daily administration of cholecystokinin-octapeptide (CCK-8) to prevent changes in hepatic bile secretory function and bile composition resulting from total parenteral nutrition (TPN) in young, growing rats. Bile was collected from the common duct before and during i.v. infusion of sodium taurocholate following 7 days of TPN. TPN resulted in a reduction of hepatic bile flow, reduced bile molar cholesterol and phospholipid content, and reduction of the taurocholate secretory rate maximum (SRm) and bile salt-independent bile flow (BSIF). Rats treated with CCK-8 throughout their TPN retained high bile flows, BSIF, and SRm. CCK-8 at the dose used did not correct abnormalities in the hepatic bile composition or the magnitude of bile flow generated in response to i.v. taurocholate infusion. These findings suggest that the ability of CCK-8 to maintain high bile flows during TPN may have prophylactic relevance for prevention of TPN-induced gallbladder disease. However, these studies also suggest that a component of current TPN systems induces damage to hepatic bile metabolism and excretion that is additional to that due to the reduced stimulation of bile flow that accompanies elimination of oral food intake.