Characterization of cadmium‐binding proteins detected in rat liver by the western blotting technique
- 1 March 1987
- journal article
- Published by Wiley in Journal of Biochemical Toxicology
- Vol. 2 (1) , 67-71
- https://doi.org/10.1002/jbt.2570020107
Abstract
Out of the three cadmium‐binding proteins (CD‐BPs) in rat liver parenchyma (40K, 29K, and 24K CdBPs), the 40K Cd‐BP showed the highest affinity for cadmium (Cd), with a dissociation constant (KD) of 1.2 × 10−8M. This is in between the affinity of human serum albumin KD = 3.8 × 10−5M) and metallothionein (KD = < 10−11). These Cd‐BPs may be responsible for hepatic sequestration of cadmium.Keywords
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