Thrombosis and Systemic Lupus Erythematosus: The Hopkins Lupus Cohort Perspective
- 1 January 1996
- journal article
- editorial
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 25 (4) , 191-193
- https://doi.org/10.3109/03009749609069986
Abstract
Vascular damage in systemic lupus erythematosus (SLE) occurs through vasculitis, premature atherosclerosis, and hypercoagulability (predominantly due to the antiphospholipid antibody syndrome). In the Hopkins Lupus Cohort, a prospective cohort study, the incidence of thrombosis is 2 per 100 person-years of follow-up. Markers of immune-complex mediated injury (high anti-dsDNA and low C3), atherosclerosis (hypertension, hyperlipidemia, homocysteine) and antiphospholipid antibodies (lupus anticoagulant or anticardiolipin) are independent predictors of thrombosis. Hydroxychloroquine use is protective against future thrombosis.Keywords
This publication has 10 references indexed in Scilit:
- Evaluating systemic lupus erythematosus disease activity using molecular markers of hemostasisArthritis & Rheumatism, 1996
- Increased release of von Willebrand factor antigen from endothelial cells by anti-DNA autoantibodies.Annals of the Rheumatic Diseases, 1996
- Effect of prednisone and hydroxychloroquine on coronary artery disease risk factors in systemic lupus erythematosus: A longitudinal data analysisThe American Journal of Medicine, 1994
- Increased thrombin generation and activity in patients with systemic lupus erythematosus and anticardiolipin antibodies: evidence for a prothrombotic state [see comments]Blood, 1993
- Lupus anticoagulant and the fibrinolytic system in young patients with stroke.Stroke, 1993
- Ticlopidine’s Mechanism of Action on Human PlateletsPublished by Springer Nature ,1993
- The atherogenic effect of lupus sera: Systemic lupus erythematosus-derived immune complexes stimulate the accumulation of cholesterol in cultured smooth muscle cells from human aortaClinical Immunology and Immunopathology, 1992
- A Randomized Study of the Effect of Withdrawing Hydroxychloroquine Sulfate in Systemic Lupus ErythematosusNew England Journal of Medicine, 1991
- Platelets and Thrombolytic TherapyNew England Journal of Medicine, 1990
- Influence of diet on vascular lesions in autoimmune-prone B/W mice.Proceedings of the National Academy of Sciences, 1983