The physiological basis for symptoms in Guillain-Barr syndrome

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Abstract
An experimental humorally induced focal demyelinative lesion of peripheral nerve is described. Associated with this lesion, conduction block appears rapidly—as early as 30 minutes in some axons—and progresses to completion within four hours. Small-diameter myelinated axons block before those of larger diameter. Recovery of conduction occurs in 6 to 15 days. This model provides a basis for understanding the time course of onset and recovery in acute Guillain-Barré syndrome and raises the possibility that a humoral mechanism might be important in the pathogenesis of the disease.