Cross-sectional Growth Study in Patients with Turner's Syndrome.

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Abstract
The body height, weight and growth velocity were investigated in 416 patients with Turner''s syndrome whose age ranged from 3 to 17 years. They were all prepubertal at the time of the present study. The chromosomal analysis revealed 45,X monosomy in 148 cases, mosaicism in 208 cases, and nonmosaic structural abnormalities of X chromosome in 60 cases. There were no significant differences in height, growth velocity and weight between the patients with the 45, X karyotype and those with other chromosomal variants at any age. Combined mean heights at 3, 10 and 17 years of age were 86.0 .+-. 3.5 (m .+-. SD), 116.7 .+-. 5.8 and 136.8 .+-. 4.8 cm, respectively. These values were -2.0 SD of normal Japanese girls. The growth velocity was 6.0 .+-. 0.5 cm/year at 4 years of age, but decreased gradually and was 1.6 .+-. 0.7 cm/year at 17 years of age. The degree of overweight was within .+-. 10% of ideal body weight for height between the ages of 3 and 8, 10-20% between the ages of 9 and 10, and 20-30% above the age of 11 years.

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