Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva
Top Cited Papers
- 1 July 2005
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 309 (5731) , 131-133
- https://doi.org/10.1126/science.1110418
Abstract
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria -specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.Keywords
This publication has 19 references indexed in Scilit:
- Genome Sequence of Theileria parva , a Bovine Pathogen That Transforms LymphocytesScience, 2005
- RAP – a putative RNA-binding domainTrends in Biochemical Sciences, 2004
- Oncogenic Action of Secreted Phospholipase A2 in Prostate CancerCancer Research, 2004
- A Theileria annulata DNA Binding Protein Localized to the Host Cell Nucleus Alters the Phenotype of a Bovine Macrophage Cell LineEukaryotic Cell, 2004
- UniProt: the Universal Protein knowledgebaseNucleic Acids Research, 2004
- The Pfam protein families databaseNucleic Acids Research, 2004
- Why are parasite contingency genes often associated with telomeres?Published by Elsevier ,2002
- Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategyOncogene, 2002
- Phylogeny and evolution of the piroplasmsParasitology, 1994
- An unusual repetitive gene family inTheileria parva which is stage-specifically transcribedMolecular and Biochemical Parasitology, 1991