Diclofenac and Enolicam as Ocular Anti-Inflammatory Drugs in Rabbit Corneal Wound Model
- 1 January 1986
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Ocular Pharmacology and Therapeutics
- Vol. 2 (2) , 171-175
- https://doi.org/10.1089/jop.1986.2.171
Abstract
The anti-inflammatory effects of two nonsteroidal agents, enolicam and diclofenac, were assessed in rabbit corneal wound model. Topically applied diclofenac (50 μl volume) at 0.01%, 0.1% and 0.5% concentrations inhibited the polymorphonuclear leukocyte (PMN) release into tear fluid following partial (6 mm central area) corneal deepithelialization in rabbits. Similarly, enolicam also inhibited this PMN response following corneal injury. Topical diclofenac was found to be more potent than topical enolicam in inhibiting the inflammatory PMN response following partial corneal injury. Both drugs did not affect the rate of reepithelialization following complete (limbal to limbal) corneal deepithelialization.Keywords
This publication has 2 references indexed in Scilit:
- The reepithelialization of rabbit cornea following partial and complete epithelial denudationExperimental Eye Research, 1977
- The mode of action of aspirin and similar compoundsJournal of Allergy and Clinical Immunology, 1976