Failure to Diagnose Cardiac Transplant Rejection with Tc-99m-PYP Images

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Abstract
The possibility of diagnosing transplant rejection using Tc-99m-PYP [pyrophosphate] imaging was examined in 12 cardiac transplant recipients. Two patients were studied on 2 occasions. Presence or absence of active rejection was established by endomyocardial biopsy. The intensity and pattern of myocardial uptake of the tracer did not differ significantly in the 2 patients studied at the time of rejection compared to the remainder. A single Tc-99m-PYP study apparently cannot be used to diagnose cardiac transplant rejection.