6-CHLORO,6-DEHYDRO,17α-ACETOXYPROGESTERONE: ITS POSSIBLE ACTION AS AN ALDOSTERONE ANTAGONIST

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Abstract
6-Chloro,6-dehydro,17α-acetoxyprogesterone (RS-1280) is a potent progestational agent, hence it was studied to determine whether or not it was an aldosterone antagonist. The study was carried out in 5 patients with cirrhosis of the liver and ascites, under constant metabolic conditions, with a previous examination of the renal capacity of each patient to excrete water, sodium and potassium under basal conditions and also when benzothiadiazine and mercurial diuretics were administered. In each case, RS-1280 was administered and its effect compared with that of a known aldosterone antagonist (spironolactone). By this means it was demonstrated that RS-1280 has no anti-aldosterone action, although it has a natriuretic effect in cirrhotic patients with a normal capacity to excrete sodium.

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