Pulmonary vascular pressure response as a function of blood flow

Publisher Website
Google Scholar
Abstract
This study evaluates the response of pulmonary artery pressure at varying levels of pulmonary blood flow after serotonin injection. Twenty-five experiments were performed in anaesthetized dogs with separate systemic and pulmonary perfusion. Pulmonary artery pressure was measured during control periods and pressure change after serotonin injection was recorded. Pulmonary blood flow was adjusted to varying levels while blood gases, left atrial pressure, and other vascular and respiratory pressures were maintained constant. Serotonin injection into the pulmonary artery (40 mcg/per kg) was performed at varying levels of pulmonary blood flow. A greater pulmonary vascular pressure response, greater change in pulmonary vascular resistance, and greater change in calculated radius and vascular smooth muscle wall tension were consistently generated with progressive increase in pulmonary blood flow. The greater vascular pressure response at higher levels of flow may be an important factor in the more rapid progression of pulmonary vascular disease in conditions with increased pulmonary blood flow.

This publication has 0 references indexed in Scilit: