On mechanisms that control heat shock transcription factor activity in metazoan cells
- 1 January 2004
- journal article
- review article
- Published by Elsevier in Cell Stress and Chaperones
- Vol. 9 (2) , 122-33
- https://doi.org/10.1379/csc-14r.1
Abstract
Heat shock factor Hsf in nonvertebrate animals and homologous heat shock factor Hsf1 in vertebrate animals are key transcriptional regulators of the stress protein response. Hsf/Hsf1 is constitutively present in cells but is, typically, only active during periods during which cells are experiencing a physical or chemical proteotoxic stress. It has become increasingly clear that regulation of Hsf/Hsf1 activity occurs at multiple levels: the oligomeric status of Hsf/Hsf1, its DNA-binding ability, posttranslational modification, transcriptional competence, nuclear/ subnuclear localization, as well as its interactions with regulatory cofactors or other transcription factors all appear to be carefully controlled. This review emphasizes work reported over the past several years suggesting that regulation at several of these levels is mediated by repressive interactions of Hsp90-containing multichaperone complexes and/or individual chaperones and Hsf/Hsf1.Keywords
This publication has 106 references indexed in Scilit:
- Elevated Expression of Heat Shock Factor (HSF) 2A Stimulates HSF1-induced Transcription during StressJournal of Biological Chemistry, 2003
- Targeted disruption of the heat shock transcription factor (hsf)‐2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesisGenesis, 2003
- Lowered Temperature Set Point for Activation of the Cellular Stress Response in T-lymphocytesJournal of Biological Chemistry, 2003
- Exogenous Expression of Heat Shock Protein 90kDa Retards the Cell Cycle and Impairs the Heat Shock ResponseExperimental Cell Research, 2002
- Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue‐specific regulation for stress‐inducible Hsp molecular chaperonesJournal of Cellular Biochemistry, 2002
- Stress-Specific Activation and Repression of Heat Shock Factors 1 and 2Molecular and Cellular Biology, 2001
- Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1The EMBO Journal, 2001
- Multiple functions ofDrosophilaheat shock transcription factorin vivoThe EMBO Journal, 1997
- Repression of human heat shock factor 1 activity at control temperature by phosphorylation.Genes & Development, 1996
- Trimerization of the heat shock transcription factor by a triple-stranded .alpha.-helical coiled-coilBiochemistry, 1992