PREPARATION OF AN INHIBITOR OF VIRAL HEMAGGLUTINATION FROM HUMAN ERYTHROCYTES
Open Access
- 1 January 1961
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 113 (1) , 37-45
- https://doi.org/10.1084/jem.113.1.37
Abstract
By manipulation of pH, hot phenolic extraction, chloroform-methanol treatment, and ultracentrifugation, a highly potent inhibitor of viral hemagglutination was obtained from human erythrocyte stroma. The inhibitor appears to be a glycoprotein containing 22-24% sialic acid, 12% hexose, 12% hexosamine, 1% fucose, and at least 11 amino acids. Sialic acid occupies a terminal position. The molecular weight is approximately 15,000. M and N blood group activity are associated with the protein.Keywords
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