An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants.
Open Access
- 1 April 1984
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 159 (4) , 1189-1200
- https://doi.org/10.1084/jem.159.4.1189
Abstract
A helper cell population with phenotypic characteristics of both B and T cells is described. This helper population, called BH, is present in normal unprimed C57BL/6 mice and preferentially helps the expression of NPb idiotype-bearing plaque-forming B cells in the absence of T helper cells. Its surface phenotype is Lyt-1.2+, Ig+, Lyb-3+, Thy-1.2-, Lyt-2.2-. The helper activity of the BH population is IgH restricted and BH cells selectively bind NPb idiotypic determinants. Evidently, this unique subpopulation can regulate the response of antibody-secreting B cells through specific recognition of idiotypic determinants.This publication has 24 references indexed in Scilit:
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