SYNAPTIC INHIBITION IN GIANT NERVE CELL OF ONCHIDIUM VERRUCULATUM

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Abstract
The membrane changes during synaptic inhibition were investigated in giant nerve cell of Onchidium verruculatum by recording either membrane potential change or the membrane current. The amplitude of the inhibitory synaptic potential or current changes linearly with the change of the membrane potential and the reversal potential is close to the resting potential. This result indicates that the primary change at the synaptic membrane is conductance increase with a certain equilibrium potential. No inhibitory effect is produced by gamma-aminobutyric acid but gamma-aminobutyrilcholine and acetylcholine produce an inhibitory effect at a concentration above 10-3[image].