Failure of mupirocin-resistant staphylococci to inactivate mupirocin

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Abstract
Isolates from four UK centres, comprising fourStaphylococcus aureus strains and oneStaphylococcus epidermidis strain with high-level mupirocin resistance, and one strain each ofStaphylococcus aureus andStaphylococcus epidermidis with low-level mupirocin resistance, were assessed for intracellular or extracellular enzymatic alteration of the antibiotic. No change was seen in a number of assays, which included comparative disk diffusion, well diffusion and high-pressure liquid chromatography. Other mechanisms of resistance need to be explored in these isolates.