Levels of erythromycin in pulmonary tissue and bronchial mucus compared to those of amoxycillin

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Abstract
Forty patients (average age 57) who had undergone surgery for bronchopulmonary cancer were divided into three groups according to antibiotic administered before operation: erythromycin ethyl succinate (1 g)—7 oral doses at 12-h intervals; amoxycillin (0·5g), 7 oral doses at 12-h intervals; erythromycin lactobionate (0·5 g), one intravenous injection on morning of surgery. Three hundred and seventy-one microbiological assays were carried out, and the following serum levels were obtained: 1·37 mg/l ± 0·89, 1h after erythromycin ethyl succinate (last dose); 3·05 mg/l ± 0·97, 1 h after injection of erythromycin lactobionate; 5·9 mg/l ± 2·63 amoxycillin, 2 h after amoxycillin (last dose). Levels of antibiotics were determined in healthy, peritumoral and tumoral tissue, in lymph nodes and in per-operation bronchial mucus. Ratios between tissue and pulmonary serum concentrations demonstrate a good diffusion of erythromycin, particularly in healthy lung = ratio of 5·47 (erythromycin per os), 4·62 (iv erythromycin) and in the tumour—3·12 (erythromycin per os) and 3·27 (iv erythromycin). These ratios are compared with those obtained for amoxycillin: 0·94 in healthy lung, 0·84 in tumour.

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