CYTOCHEMICAL EVIDENCE FOR AEROBIC PATHWAYS IN MYCOBACTERIUM-LEPRAEMURIUM

  • 1 January 1977
    • journal article
    • research article
    • Vol. 45  (1) , 9-13
Abstract
Three enzymes of aerobic pathways (cytochrome c oxidase, peroxidase and catalase) and 1 key enzyme of the tricarboxylic acid cycle (succinate dehydrogenase) were investigated for their ultrastructural localization in M. lepraemurium in infected mouse liver and in cultures of M. fortuitum as a control. All 4 enzymes were localized in M. fortuitum. To M. lepraemurium only cytochrome c oxidase and peroxidatic activity were detected. The localization of the latter enzyme activity was different compared with M. fortuitum. Succinate dehydrogenase was not detected in M. lepraemurium but was found in the membrane of the phagosomes containing the bacteria. M. lepraemurium can function aerobically and has either a glyoxalate pathway or is an obligate autotroph.

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