CHARACTERIZATION OF GLUCURONIDE METABOLITES OF CARBAMAZEPINE IN HUMAN URINE BY GAS-CHROMATOGRAPHY AND MASS-SPECTROMETRY

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 6  (4) , 494-501
Abstract
Glucuronide metabolites of carbamazepine (5H-dibenz[b,f]azepine-5-carboxamide) [a drug commonly used for the treatment of convulsive disorders and trigeminal neuralgia] were identified in human urine following chromatography on XAD-2 resin, permethylation and combined gas chromatography and mass spectrometry with an SE-30 capillary column. Eight glucuronide metabolites, previously unidentified in man, were characterized as their permethylated derivatives. These included carbamazepine N-glucuronide .**GRAPHIC**. 3 isomers of dihydroxycarbamazepine O-glucuronide .**GRAPHIC**. 3 isomers of hydroxymethoxycarbamazepine O-glucuronide .**GRAPHIC**. and 1 isomer of hydroxycarbamazepine O-glucuronide .**GRAPHIC**. Other glucuronide metabolites, previously identified following enzymatic hydrolysis, were characterized as the unhydrolyzed, permethylated glucuronides, 10,11-dihydro-10,11-di-hydroxy carbamazepine O-glucuronide .**GRAPHIC**. and 3 isomers of monohydroxycarbamazepine O-glucuronide .**GRAPHIC**.

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