Long-Term Exposure of Plaque to Zinc Citrate

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Abstract
The effect of 3 years’ continuous exposure to dentifrices containing different levels of sodium monofluorophosphate, with or without 0.5% zinc citrate, has been investigated on plaque growth inhibition. Additionally, changes in the plaque microflora during prolonged exposure to zinc have been monitored in children with high or low caries increments. Following long-term use the inhibitory effect of zinc citrate on plaque growth was fully maintained. There was no evidence that prolonged exposure to zinc caused shifts in the plaque population of Streptococcus mutans, Streptococcus sanguis, lactobacilli, or Actinomyces species. A positive association was observed between children with high caries increments and high numbers of S. mutans in plaque and saliva. Caries increments were also associated with total viable count per microgram plaque protein. A negative association was observed between combined caries increment and number of S. sanguis in plaque.

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