ENOLASE ISOENZYMES IN BENIGN AND MALIGNANT MELANOCYTIC LESIONS

1 January 1982

journal article
research article

Vol. 5 (3) , 175-181

Abstract

Distributions of the .alpha., .beta. and .gamma. subunits of enolase were studied in 34 human melanocytic lesions using the peroxidase-antiperoxidase (PAP) technique. Melanocytes in benign neoplasms stained moderately strongly for both .alpha. enolase and .gamma. enolase but staining for .beta. enolase was consistently negative. Staining for .alpha. enolase was always stronger than that for .gamma. enolase. There are some indications that with increasing degrees of dedifferentiation there was a reduction of .gamma. enolase activity, least differentiated cells being completely negative. Ocular melanomata showed similar changes to those seen in the skin. The enolase isoenzyme composition of tumor extracts was assessed biochemically on a limited number of cases and the results are discussed in relationship to the immunohistochemical studies.

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