Photoacoustic tomography of the mouse cerebral cortex with a high-numerical-aperture-based virtual point detector

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Abstract
Photoacoustic tomography (PAT) is an emerging biomedical imaging modality, which detects optical absorbers, such as blood vessels, inside tissue. Based on the photoacoustic mechanism,1, 2 PAT uses an nonionizing illumination source and is noninvasive. Moreover, by using diffused light instead of ballistic light, PAT can image deeper into tissue than other pure high-resolution optical imaging methods, such as optical coherence tomography (OCT) and two-photon tomography. PAT has been successfully applied in imaging both small-animal and human tissues.3, 4, 5