Lack of evidence for hepatitis B virus (HBV) infection in fulminant non-A, non-B hepatitis
- 1 August 1994
- journal article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 39 (8) , 1677-1682
- https://doi.org/10.1007/bf02087775
Abstract
We studied eight patients who had orthotopic liver transplantation for fulminant hepatic failure in the course of acute non-A, non-B hepatitis. HBV DNA was searched for extensively in the liver tissue by PCR using several sets of primers in conventional and heminested reactions. All patients were negative for HBV DNA in liver tissue by all assays employed; furthermore, they were negative for HEV RNA, HCV RNA, and HBV DNA in serum. Although the causative role of HEV and HCV in fulminant non-A, non-B hepatitis cannot be excluded, our data do not support a causative association between this syndrome and HBV infection.Keywords
This publication has 9 references indexed in Scilit:
- Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United StatesGastroenterology, 1993
- Hepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant hepatitisGastroenterology, 1993
- Fulminant or subfulminant non-A, non-B viral hepatitis: The role of hepatitis C and E virusesGastroenterology, 1993
- Hepatitis B virus and apparent fulminant non-A, non-B hepatitisThe Lancet, 1992
- Enzyme-linked immunosorbent assay for diagnosis of acute sporadic hepatitis E in Egyptian childrenThe Lancet, 1992
- Characterization of a prototype strain of hepatitis E virus.Proceedings of the National Academy of Sciences, 1992
- Hepatitis C Virus in Fulminant Hepatic FailureNew England Journal of Medicine, 1991
- Mutations in the Precore Region of Hepatitis B Virus DNA in Patients with Fulminant and Severe HepatitisNew England Journal of Medicine, 1991
- Fulminant and Subfulminant Liver Failure: Definitions and CausesSeminars in Liver Disease, 1986