Majorenolide and Majorynolide: A New Pair of Cytotoxic and Pesticidal Alkene-Alkyne δ-Lactones from Persea major
- 1 November 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 52 (6) , 1263-1266
- https://doi.org/10.1021/np50066a011
Abstract
From the EtOH extract of the bark of Persea major, two bioactive compounds, majorynolide [1] and majorenolide [2], were isolated by activity-directed fractionation using brine shrimp. Their structures have been elucidated on the basis of spectral data as a pair of new alkene-alkyne .delta.-lactones, each with an exocyclic, alkylidene methine carbon. Both 1 and 2 are moderately cytotoxic, and 2 is selectively pesticidal.This publication has 1 reference indexed in Scilit:
- Modification and Evaluation of the Potato Disc Assay and Antitumor Screening of Euphorbiaceae SeedsJournal of Natural Products, 1982