CLINICAL EXPERIENCE WITH ISOFLURANE (FORANE )

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Abstract
The clinical anaesthetic course of 100 patients anaesthetized with isoflurane is described. Induction techniques with isoflurane oxygen, nitrous oxide-isoflurane-oxygen, or intravenous thiopentone were devoid of serious complications, the worst being mild excitement. Relaxation for tracheal intubation was excellent. Maintenance of anaesthesia was characterized by respiratory depression, slight hypotension and tachycardia, good muscle relaxation, compatibility with adrenaline and phenylephrine, absence of ventricular arrhythmias, twitching, convulsions or e.e.g. seizure patterns. Nitrous oxide and narcotics decreased the required inspired isoflurane concentration for the same level of anaesthesia. Small doses of tubocurarine produced adequate relaxation. Awakening was rapid, accompanied by pain and shivering in a large proportion of patients. No hypotension was seen during recovery. No postanaesthetic complications were observed.

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