Studies in Immunodermatology

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Abstract
Intraepidermal changes resulted from intradermal injections of rabbits with sera of patients suffering from Brazilian pemphigus foliaceus which contained high titers of pemphigus antibodies when followed immediately by treatment with a 1% or 2% solution of 2,4-dinitrochlorobenzene. Preliminary studies yielded epidermal changes including microbullae which were characteristic of those seen in human pemphigus both by immunofluorescence and by histopathology. In further experiments, intraepidermal clefts associated with strong in vivo binding of pemphigus antibodies appeared, in sections examined by immunofluorescent staining for human IgG, without typical acantholytic cells in these clefts.

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