The Binding Constant of ATP to Myosin S1 Fragment

Abstract
The extent of ATP synthesis from ADP and Pi at the active center of rabbit myosin subfragment 1 was reinvestigated. The results were interpreted using a treatment which was not dependent on the number or nature of the intermediates in the ATPase mechanism. An average value for the binding constant of ATP of (3.25 .+-. 0.96) .times. 1011 M-1 at pH 8.0, 23.degree. C and ionic strength 0.12 M was obtained.