PLATELET FACTOR-3 IMMUNO-INJURY TECHNIQUE RE-EVALUATED - DEVELOPMENT OF A RAPID TEST FOR ANTIPLATELET ANTIBODY - DETECTION IN VARIOUS CLINICAL DISORDERS, INCLUDING IMMUNOLOGICAL DRUG-INDUCED AND NEONATAL THROMBOCYTOPENIAS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 89  (2) , 400-408
Abstract
A modified version of the platelet factor 3 immunoinjury technique for the detection of antiplatelet antibody is described in detail; heat-inactivated sera and frozen platelets are employed. The modification allows the results of the test to be available within 4-5 h after drawing the blood sample, in contrast to the 3 days required in the original method. The technical work involved is significantly reduced. The reproducibility of the technique is improved. Results obtained with the 2 tests correlate well. Data accumulated in 458 cases of clinical disorders associated with antiplatelet antibody are reported. Drug-dependent antiplatelet antibody was demonstrated in 26 cases of thrombocytopenia associated with 19 different drugs. Data are also presented for 23 cases of [human] neonatal thrombocytopenia.

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