Tumor Necrosis Factor Receptor Superfamily 12 may Destabilize Atherosclerotic Plaques by Inducing Matrix Metalloproteinases
Open Access
- 1 January 2001
- journal article
- Published by Japanese Circulation Society in Japanese Circulation Journal
- Vol. 65 (2) , 136-138
- https://doi.org/10.1253/jcj.65.136
Abstract
Immunohistochemical staining of human atherosclerotic plaques revealed expression of the tumor necrosis factor receptor superfamily (TNFRSF) 12 in regions rich in macrophage/foam cells. The role of TNFRSF12 in the functioning of monocytes in relation to atherogenesis was investigated by analysis of cellular events after stimulation of TNFRSF12 in a human macrophage-like cell line, THP-1. Activation of the THP-1 cells on plates coated with monoclonal antibody against TNFRSF12 induced the expression of matrix metalloproteinases (MMPs) -1, -9, and -13. Furthermore, the expression patterns of TNFRSF12 and the MMPs overlapped in atherosclerotic plaques. Signaling of TNFRSF12 may thus contribute to the induction of extracellular matrix degrading enzymes in macrophages. (Jpn Circ J 2001; 65: 136 - 138)Keywords
This publication has 8 references indexed in Scilit:
- Increased Matrix Metalloproteinase-9 Activity in Unstable Carotid PlaquesStroke, 2000
- Evidence for Increased Collagenolysis by Interstitial Collagenases-1 and -3 in Vulnerable Human Atheromatous PlaquesCirculation, 1999
- New Insights into Plaque Stabilisation by Lipid LoweringDrugs, 1998
- TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces ApoptosisJournal of Biological Chemistry, 1997
- Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95Science, 1996
- The CD40 Antigen and Its LigandAnnual Review of Immunology, 1994
- Tumor necrosis factor-alpha in human arterial wall with atherosclerosisAtherosclerosis, 1991
- Detergent-activation of latent collagenase and resolution of its component moleculesBiochemical and Biophysical Research Communications, 1982