Retinoic Acid Receptor and Telomerase Catalytic Subunit Expression in Bronchial Epithelium of Heavy Smokers
Open Access
- 15 January 2003
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 95 (2) , 165-168
- https://doi.org/10.1093/jnci/95.2.165
Abstract
Expression of retinoic acid receptor β (RARβ) and telomerase catalytic subunit (human telomerase reverse transcriptase [hTERT]) was analyzed in 285 bronchial biopsy specimens from 53 heavy cigarette smokers and four former smokers by using in situ hybridization. Of the 191 biopsy specimens that were positive for RARβ, 69% expressed hTERT, whereas only 54% of the 94 RARβ negative biopsy specimens expressed hTERT (P = .014). Because hTERT expression in bronchial tissue has been previously associated with increased risk of lung cancer, the association between RARβ and hTERT expression suggests that RARβ expression may be an indicator of increased risk of lung cancer in heavy smokers.Keywords
This publication has 25 references indexed in Scilit:
- Molecular genetic abnormalities in the pathogenesis of human lung cancerPathology and Oncology Research, 2001
- Promoter Methylation and Silencing of the Retinoic Acid Receptor- Gene in Lung CarcinomasJNCI Journal of the National Cancer Institute, 2000
- RARβ2 specificity in mediating RA inhibition of growth of lung cancer-derived cellsLung Cancer, 2000
- Placebo-Controlled Trial of 13-cis-Retinoic Acid Activity on Retinoic Acid Receptor-Beta Expression in a Population at High Risk: Implications for Chemoprevention of Lung CancerJournal of Clinical Oncology, 1999
- Nuclear Retinoid Acid Receptor Beta in Bronchial Epithelium of Smokers Before and During ChemopreventionJNCI Journal of the National Cancer Institute, 1999
- Expression of Retinoid Receptor Genes and Proteins in Non-Small-Cell Lung CancerJNCI Journal of the National Cancer Institute, 1999
- Regulation of RARβ expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: Effect on growth inhibition and apoptosis inductionInternational Journal of Cancer, 1998
- Suppression of Retinoic Acid Receptor in Non-Small-Cell Lung Cancer In Vivo: Implications for Lung Cancer DevelopmentJNCI Journal of the National Cancer Institute, 1997
- Lung tumors in mice expressing an antisense RARβ2 transgeneThe FASEB Journal, 1996
- Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells.Proceedings of the National Academy of Sciences, 1993