Transport of 3-methoxy-4-hydroxymandelic acid by isolated rat choroid plexus
- 1 February 1976
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 1 (1) , 47-52
- https://doi.org/10.1007/bf00965630
Abstract
3-Methoxy-4-hydroxymandelic acid (VMA) is transported into the isolated choroid plexus against a concentration gradient by a saturable, energy-dependent system. The apparentK m for transport is 35 nM and theV max is 1 pmol/mg tissue/hr. Concentrations of probenecid (0.1 mM) that block the transport of other acidic biogenic amine metabolites did not block the transport of VMA. The transport system of the choroid plexus probably plays a role in clearing VMA from the CSF.This publication has 10 references indexed in Scilit:
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