Analgesic effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake.

  • 1 January 1975
    • journal article
    • Vol. 1  (5) , 511-21
Abstract
Rats treated with Lilly 110140, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock. Lilly 110140 antagonizes the hyperalgesia following injections of p-chlorophenylalanine and potentiates morphine analgesia. Naloxone blocks the analgesia following morphine, but has no effect on Lilly 110140-induced analgesia. Brain serotonin neurons may, at least in part, mediate analgesia.

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