Transient Secretion of Phosphate in the Mammalian Kidney

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Abstract
Transient renal responses to close arterial instantaneous injections of NaH2PO4 and creatinine were studied in dogs with plasma phosphate maintained at 3 mmole/l. One ml of a solution of 0.5 [image] creatinine and 0.5 [image] NaH2PO4 was injected when urine flow had reached levels of 8-12 ml/min/kidney. A solution of 1.0 [image] mannitol was employed as the diuretic agent. The increment of phosphate excretion per unit injected per one circulation of injected substance was greater than that of creatinine. Ratios of incremental phosphate to incremental creatinine were 1.5-9.0, particularly during the downsweep of excretion curves. Such findings, interpreted as net minimal secretion of phosphate into the renal tubule, were found in 8 consecutive experiments.

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