In patients with Hodgkin's disease involvement of the skin by any of several lesions is well recognized. The onset of ichthyosis vulgaris in an adult with no previous personal or familial history of this disease is unusual. Therefore, the simultaneous occurrence of Hodgkin's disease and ichthyosis leads one to suspect a cause and effect relationship. Two cases of this combination have previously been reported.1 In addition, one case of lymphosarcoma has been reported accompanied by acquired ichthyosis.2 This association is considered to be of interest because the onset of ichthyosis in a patient with no other visible lesions may be the clue to an otherwise occult Hodgkin's disease or lymphosarcoma. In the following patient, the cutaneous lesion was the presenting complaint. A single painless lymph node was all but unnoticed by him; yet it disclosed the histologic diagnosis of Hodgkin's disease. From the dermatologic standpoint, the acquired ichthyosis