Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine

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Abstract
Summary: Amphetamine sulphate (5 mg/kg), administered intraperitoneally, reduces the concentration of glycogen in the mouse brain by 25–30% after 30 minutes. The effect of several receptor blocking drugs on the amphetamine‐induced cerebral glycogenolysis was studied. dl‐Propranolol (0·25 mg/kg) and pronethalol (10 mg/kg) antagonized the depletion of brain glycogen by amphetamine. Phentolamine, methysergide, atropine and mepyramine failed to antagonize the amphetamine‐induced glycogenolysis. d‐Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses. It is concluded that amphetamine‐induced glycogenolysis in the mouse brain may be mediated through a β‐adrenoceptor.