A simple method based on broken‐line interpolation for displaying data from long‐term clinical trials

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Abstract
In displaying data from long‐term clinical studies, variation across patients in the times at which readings are recorded often presents a problem. A simple method for treating such data is proposed, which avoids arbitrary conventions and methodological difficulties inherent in other approaches. It is based on within‐patient broken‐line interpolation, and is easy to implement on a computer. The method is tested and compared to others with computer‐simulated data whose time‐pattern is known. Though the comparison is of limited scope, the method appears to compare favourably with the ‘closest‐reading’ and ‘window’ approaches.

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